Endocrine Abstracts

Background: Daily injection of progesterone in men is reported to suppress the pituitary LH response to GnRH challenge. We hypothesized that the progesterone nuclear hormone receptor antagonist mifepristone (RU486) would reverse these effects.Study design: Open–label randomised, three period crossover-over study in 12 healthy male subjects. Subjects were treated for 8 days with A/ progesterone 50 mg (IM) alone; B/ progesterone 50 mg + mifepristone 1...

Temporary hypocalcaemia following total thyroidectomy occurs in around 30% of patients and is usually due to inadvertent damage to the parathyroid glands. Whilst mild cases are easily managed with oral calcium supplementation, there is the potential for severe calcium deficit with the ensuing risks of cardiac dysrhythmias, tetany and in extreme cases death. It is common practice to have a post-surgery protocol to allow the early identification of these patients. Whilst many pr...

As per NICE guideline, referral for parathyroidectomy need to be according the below, • symptoms of hypercalcaemia or • End-organ disease (renal stones, fragility fractures or osteoporosis) or • An albumin-adjusted serum calcium level of 2.85 mmol/litre or above.Methods: We conducted a retrospective analysis of investigations done as per recommendation of NICE guidelines for patients who underwent Parathyroidectomy under t...